Tuesday, May 3, 2016

The Importance of Exploring Your Child’s Personality

Parents and caregivers frequently ask prescribers for medications for children’s problematic behaviors especially ones associated with hyperactivity and inattentiveness.  Instead of writing medications on a scriptpad, prescribers should more often choose to write down this message, “get to know your child’s personality.”  Children with a couple of problem behaviors, do not suffer from the all too common disorder known as ADHD, rather they function within the normal range of behavior which may include among other things having an outgoing personality.  Instead of doing schoolwork, some kids prefer to socialize during group time.  In this example, neither diagnosis nor medication is indicated for these children, rather, the appropriate treatment includes guidance and reassurance for caregivers.
Child Psychiatry is both a noble profession and extremely effective when practiced correctly. I must clearly state that I do not aim to limit psychiatric diagnosis and treatment desperately needed by so many children.  Those who do need treatment should seek it out and continue it. I do aim, however, to alert parents that some children do not need treatment and should avoid it.  Whatever the case may be, understanding a child’s personality is still key to both managing problematic behaviors and ultimately to a child’s success.
Why is understanding personality so important? The human brain is the ultimate computer.  Different people are “hardwired” from their DNA with different skills and abilities that form their personality. Most dominant personality traits become apparent in early childhood and remain constant throughout one’s life.  New evidence supports that one’s personality has more influence on success than even intelligence.
To people, young or old, figuring out what makes their personality unique is of extreme importance.  The earlier this information about personality is known in life, the more beneficial it can be.  It can aid in helping children navigate the ups and downs of young personhood, always a daunting expedition!  The better your understanding of a child’s personality, the better job you can do in supporting a child while he or she explores both the strengths that come naturally to his or her particular personality type as well as the areas that need further development.
Knowing oneself well is the key to being successful at school, at home, and in relationships. Because knowing oneself is perhaps the single most important life achievement, teaching children to not only know themselves but to know themselves as early as possible may be the single most important gift you could give them. Knowing oneself both well and early means making better decisions at a younger age about what you want to be, where you want to go, who you want to take along with you, and above all, how to achieve one’s own personal version of success.
Whether you are a kid just starting out on your personality expedition, or an adult helping children start their quest, your primary objective is the same, learn and share this most important message that my grandfather once shared with me: “Success is to know oneself.  Knowing oneself means knowing what makes one happy. Create your life around this principle to be successful.”
Want to learn how to better understand your child’s personality?  Look for my website www.DrOree.com coming soon!  Like my page on facebook and subscribe to my blog!

Tuesday, April 26, 2016

BIG PHARMA: PSYCHIATRY'S SECRET PUPPETEER

American “big pharma” reached deep into psychiatric research through its influence on university psychiatrists even at my own alma mater, Emory University. In the span of two years, I saw Emory’s Department of Psychiatry go from the most distinguished on campus to the one with a most dubious distinction, all because of one thing: an unethical relationship with “big pharma.”
When I began my residency in 2005, Emory’s Department of Psychiatry was arguably one of the top programs in the Southeast and by 2007 our program was ranked highest nationally over all other medical departments at Emory University.  That year a large banner congratulating our department hung on the crosswalk that led over the busiest street on Emory’s campus.  This success was largely due to the leadership and research contributions of our chair and his ties to the pharmaceutical industry.  
In 2008, Senator Charles Grassly led a congressional investigation which revealed that many well known university psychiatrists had violated federal and university regulations by accepting millions of dollars in undisclosed amounts from pharmaceutical companies.  Through their research, these psychiatrists promoted the use of psychiatric drugs manufactured by the companies that secretly paid them loads of cash.  
The chair of of our department was among these doctors. He later resigned from his position after failing to report a third of the $2.8 million in consulting fees he received from GlaxoSmithKline.  Because of our departmental connections with the pharmaceutical industry, Emory banned pharmaceutical representatives from campus altogether.  
Our psychiatry department, however, wasn’t the only one in bed with “big pharma.” A highly influential Harvard University child psychiatrist, Dr. Joseph Beiderman, was also investigated by Senator Grassley and was found to have violated conflict-of-interest policies for receiving millions in undisclosed funds from pharmaceuticals which he promoted to treat children.  He was later disciplined by Harvard for these violations but not before significant damage had been done.
Despite the resulting increase in federal regulations regarding relationships between “big pharma” and research psychiatrists, the pharma puppetmaster continues to influence psychiatry today, though now in less obvious ways.  The financial and professional links which now exist between psychiatry and pharmaceutical companies are protected for both the physician and the pharma company through the guise of “full disclosure.” Drug companies still fund much of the research conducted by psychiatrists, but now, the doctors “fully disclose” this relationship--in the fine print.  Drug companies also advertise medication in psychiatric journals and at medical conferences, fund psychiatric and healthcare organizations, and send representatives to lobby influential physicians and politicians.
Before these new regulations went into effect, Dr. Beiderman and his team had been producing medical literature to raise awareness of Childhood Bipolar Disorder, as well as endorsing its treatment with atypical antipsychotics, for over a decade.  His team suggested that because of a child's undeveloped brain, bipolar disorder has a different clinical presentation in children than is typically seen in adults. Supporters of Dr. Beiderman’s work lobbied enthusiastically for inclusion of Childhood Bipolar Disorder in DSM-IV, but the committee at that time found the scientific support unconvincing and refused to do so.
Despite the snub by DSM-IV, child psychiatrists and pediatricians throughout the US, highly influenced by Dr. Beiderman’s work, increased the diagnosis of childhood bipolar disorder and its treatment with atypical antipsychotics.  Childhood bipolar disorder, once rare, then became common. In only fifteen years, rates jumped an astounding forty-fold. Much to the delight of manufacturers of antipsychotics, prescriptions written for their products soared as child after child began taking these medications.
Of all classes of psychiatric medication, antipsychotics arguably carry the most burdensome short term and long term side effects. Children taking them are more likely to suffer short-term effects, and in more severe ways, because of their immature brains.  Long term side effects can also be severe in children. Because very little research has been done, the long-term risk, although estimated to be high, is unknown.
Antipsychotics are divided into two classes: typical (first generation antipsychotics) and atypical (second generation antipsychotics).  Both classes carry some of the same side effects, but the atypical antipsychotics are widely known for their most problematic side effect--weight gain.  Due to weight gain and the associated complications of obesity, a baseline weight, cholesterol panel, and blood glucose level should be obtained before use, and each should be routinely monitored.  
Lack of knowledge of when and how to properly use antipsychotics, as well as an understanding of their side effects, has not stopped their increasing use in America’s children, especially the use of atypical antipsychotics.  According to the 2011 report from Medicaid, “children taking antipsychotic medications receive an atypical antipsychotic 90 percent of the time and in the majority of patients the use is for an off-label indication. Frequent off-label uses include treating aggressive, disruptive, and hyperactive children.  The FDA has not approved use of antipsychotics in any children under age five, although I have on several occasions discontinued these medications in five-year-olds.
Drug companies promoted unapproved uses for their products among child psychiatrists and pediatricians alike.  Meanwhile, nonstop magazine, TV, and internet direct-to-consumer advertising reached families struggling with aggressive children.  These families, once mystified by their child’s of out-of-control behavior, now had a medical model for understanding their child.  This medical model not only benefited the drug companies, but also provided parents with a more acceptable explanation of, and solution for, their child’s problem.
Teachers also tend to exert pressure on parents to medicate their children rather than to collaborate with caregivers on non-medical therapies.  So, who can blame these families for trying medication as an option for treating their child's aggression when they face so many pressures to do so?  Their child's repeated aggressive actions in the classroom result in multiple calls from teachers. Continually being called to pick up a dysregulated child often goes far beyond simply trying a parent's patience. Especially in the case of single working mothers, of whom there are many, continual disruptions can affect their jobs, even to the point of being fired.
Teachers, though, may also feel pressured. They find that medicating takes less time and results in an improved learning atmosphere for the rest of the students.  After all, they cannot continue to tolerate a child's aggressive behavior if it risks their safety or the safety of other students. When that point is reached, a child may be expelled, risk legal charges, or be transferred to an alternative school.  Alternative schools group children with behavior problems together, hence producing a more stressful learning environment, a situation that only exacerbates an already aggressive child's condition. Neither temporary subdual nor bodily removal solves the child’s problem.
What can be done?  A preschooler who bites and spends long periods of time struggling through raging meltdowns needs help. Too often, the available psychotherapeutic services are minimal and don’t fully meet the child's need for treatment. Driving to and from therapy is expensive and often waiting lists are full.  Funding has been slashed for social safety nets such as county mental health programs that could connect kids to, and often pay for, psychotherapy or for skills groups such social skills training and anger management training or, more importantly, provide parent education on how to handle behavioral problems on their own through learning basic behavioral modification.
It's understandable that medication from a pediatrician would be considered if other treatments are not readily available. Pediatricians fill these holes in our social safety net by prescribing antipsychotics to aggressive children.  However, most of these children have not even been diagnosed with a mental disorder by the pediatrician before being prescribed antipsychotics.
According to a study, “‘primary care practitioners provide a larger percentage of psychotropic drug visits than psychiatrists in every psychotropic class except lithium. In all therapeutic classes, when a psychotropic medication was prescribed, psychiatrists typically provided a mental health diagnosis, while primary care physicians did not.”  Antipsychotics quickly prescribed to five-year-olds who are not psychotic and who have not been diagnosed with any mental health disorder is exploitation.
Antipsychotic medications have serious side effects and can oftentimes do more harm than good.  These medications are known to increase the appetite, causing weight gain, raising blood glucose and increasing the risk of diabetes. They are also sedating, leaving a child asleep at his desk for most of the day. These are some shorter-term consequences; the long-term consequences are largely unknown.
In some cases, though, the side effects of these medications must be outweighed by the possible consequences of violent children who seriously injure others and face legal charges. Thoughtful doctors do use atypical antipsychotics appropriately in aggressive children after all other options have been considered.
I have used atypical antipsychotic in young children in severe situations, such as repeated violence towards others in acute psychiatric hospitals and in residential treatment facilities.The benefit of the medication can be likened to a band-aid in that its sedative effects provide only a temporary solution, but do not address the underlying problem, whatever it may be.  Aggression is nonspecific in children and can result from many different things such as anxiety, extensive physical abuse histories, or having to continuously protect themselves from older children they encounter in the behavioral health care system.
Some adolescents and, less frequently, children do, indeed, have early onset bipolar disorder.  Clearly, however,  Dr. Biederman along with “big pharma” greatly changed mental health treatment for aggressive children by considerably increasing the use of antipsychotic medications and other bipolar medications, known as mood stabilizers. These medicines have proven  effective for the treatment of bipolar disorder in adults and carry FDA indications of such. They have proven less effective for children. We do a disservice to our children when we treat them as “mini-adults.” Treatment considered effective for adults is not automatically effective for children because the range of normal behavior in adults is very different from the range of normal behavior in children.
Both on- and off- label use of psychiatric medication in children and adolescents have increased rapidly in the last ten years.  Pediatricians and family care doctors are not experts at prescribing psychiatric medicine, yet they write most psychiatric prescriptions for children. Because they have not been trained in non-medicinal treatment options, they use what they know--medications.  They are unaware of treatment alternatives to medications which might be a better solution for the child in the long run because they’ve never been trained in psychotherapy modalities.
And what became of pediatric bipolar disorder? Something similar debuted in the new DSM but has been labeled as a different disorder: Disruptive Mood Dysregulation Disorder. The debut of DSM-V and especially its changes in the classification of childhood disorders was met with much controversy.  A major blow to the APA came when the National Institute for Mental Health (NIMH), the largest funding agency for mental health research, withdrew support of the document and declared that it would no longer fund research that relied solely on the DSM-V.  The NIMH made it clear to the AMA and the rest of the world that the  DSM-V didn’t have enough scientific evidence to fully support its use.  The disorder most cited for DSM-V’s lack of scientific evidence is the new disorder for children, Disruptive Mood Dysregulation Disorder.
Because this is a newly named disorder, how could there possibly be enough evidence from valid research to support its inclusion?  It’s been studied by only one group and for only six years.  The clinical implications of this new disorder have been highly theorized, but remain to be seen.
Writing a script is easy and a lot less time consuming than doing a thorough psychiatric assessment or participating in psychotherapy.  It also works faster and in some cases is even cheaper than psychotherapy.  But is it safest and wisest choice for our children?  The puppetmaster says, “Yes!”

Thursday, April 21, 2016

ADHD: The Public Health Fad That Won't Fade

Some public health fads, sensationalized by the media, come and go rather quickly.  Others take root and significantly change the way Americans view the health and wellness needs of their children.  Take, for example, wisdom teeth extraction. You’ve probably heard the old tale that because wisdom teeth cause all sorts of problems, young people should have them extracted as a preventive measure.  After close examination of the evidence, you will find that this simply is not true. According to an article in the American Journal of Public Health, wisdom teeth extraction is a public health hazard and should be avoided (Friedman,1554). Wisdom teeth extraction, however, continues to be a big money maker for the dental industry at around a billion dollars a year.   
Another public health fad that has changed American culture, became a public health hazard and continues as a big money maker for the behavioral health industry: using psychostimulants to treat hyperactivity and inattentiveness in children.  Yet, hyperactivity and inattentiveness are expected behaviors of an undeveloped brain and do not necessarily indicate ADHD (attention deficit hyperactivity disorder). Over the last twenty years America’s children, some diagnosed with ADHD and some only presenting associated symptoms, have been prescribed stimulants at increasing and alarming amounts.  
Since 1990, the number of America's children taking stimulants has soared from 600,000 to about four million (Safer, 1084).  These numbers which appear to represent a burgeoning ADHD epidemic actually only reflect the pharmaceutical companies’ marketing skills.“Big pharma” moved into a booming children’s market by funding multiple studies that show psychostimulants to be the most efficacious treatment for ADHD in kids. According to analysis of CDC data, ADHD is now one of the most frequent long term diagnoses of children.
Funded by pharmaceutical companies, the prominent Harvard child psychiatrist, Dr. Joseph Biederman, produced multiple research articles embracing the use of stimulants in children.  Dr. Biederman has been called by other physicians, “unequivocally the most published psychopharmacology maven for ADHD.”  Frequently cited by pharmaceutical representatives, his work delivers three messages:  ADHD is underdiagnosed, stimulants are safe and effective treatment for ADHD, and unmedicated ADHD poses significant risks.  Although investigated by Congress and sanctioned by Harvard for conflict of interest violations, Dr. Biederman has produced research that has drastically changed the way American physicians both diagnose ADHD and treat ADHD with psychostimulants in children.
Stimulants will indeed make an inattentive child pay attention.  Parents almost overnight will see an improvement in school work.  Teachers, who previously called daily about a disruptive child, stop calling.  For a few months, the medication works like a miracle pill.  Gradually the calls start again as behavior slips back to what is was before the start of medication.  Another trip to the doctor and the dose is increased due to a phenomenon known as “tolerance,” repeated use that results in diminished returns.  Dosage is increased gradually over months to the maximum recommended,  but even at levels this high, tolerance continues to reduce efficacy.  The child is later switched to a different stimulant  in a different class and once again the dosage climbs the tolerance ladder. It is not uncommon for me to evaluate a child and hear the caregiver state, “Oh, my child has tried every medicine there is for ADHD.”
The long term impact of stimulants on the developing brain of a child is unknown. Pertinent unanswered questions include the following:
1.    How does the stimulant affect dopamine (a neurotransmitter which neurons use to communicate with each other)?
2.   Does the stimulant increase the risk for a substance abuse disorder later in life?  
3.   Will the stimulant affect a child’s physical growth?
Presently, no one can supply precise answers to these questions for few long-term studies addressing them have been completed.
Certainly, ADHD is a real disorder. Its existence has been supported by sound scientific research. It legitimately disables those who suffer from it at school and in their interpersonal relationships. Since no definitive test exists, final interpretation of symptoms is left up to the diagnosing clinician. Rating scales should be completed by parents and teachers before and throughout the management of a child’s treatment with stimulants for ADHD.  Examples of these scales include the Conners’ Parent Rating Scale, the Conners’ Teacher Rating Scale and the Child Behavior Checklist.
 A ten-year-old patient, whom I will refer to as John, was doing a lot better in school after nine months on stimulant medication.  Concerned about potential side effects, his mom asked that his medication be tapered down and discontinued. After three months off medication, John was failing subjects again, and he was no longer getting invited to birthday parties.  Because of the decline in his academic performance and in his social standing, John’s self esteem also took a blow.  For children who legitimately have ADHD, stimulants may be a necessary risk to advance academically and to maintain social relationships.  Their use, however, but must be carefully considered and closely monitored.   
An increasing number of parents are seeking to have their children evaluated for ADHD. Poor grades, absent mindedness, and class disruption are now being used as grounds for a stimulant prescription rather than a diagnosis of ADHD based on more objective data such as rating scales or direct observation. The pharma advertising leaves physicians reasoning that if a stimulant helped children with ADHD, then perhaps it can also help children without ADHD who are struggling with the same issues. Physicians will claim to be uninfluenced by pharmaceutical marketing, but years of research, however, suggest otherwise.  We are all influenced by advertising and other social pressures to at least some degree.
The FDA has cited “big pharma” for false and misleading advertising regarding the use of stimulants many times.  Shire, a leading producer of stimulants, has gone as far as subsidizing the production of comic books that market directly to children. On these pages, superheroes encourage children to take medicine to control their behavior.  Given the high abuse potential of stimulants, regulations that allow such marketing does not afford enough protection. Instead, direct consumer marketing of controlled substances, especially to children, should be illegal.
Many risks are involved in the use of stimulants. The FDA has labeled stimulants with  a black box warning (their strictest warning) because of their high abuse potential, cardiovascular complications, and association with sudden death.  Other side effects include loss of appetite, weight loss, insomnia, irritability, anxiety, abnormal involuntary movements, and hallucinations.  Children frequently require additional medications just to address the side effects associated with stimulants.
I evaluated a child in the emergency room of a large pediatric hospital for hallucinations.  The seven-year-old girl, whom I will call “Sarah,” stated tearfully, “I feel bugs crawlin’ on me! Look! See!” Despite her mom’s reassurance that she didn’t have bugs on her, Sarah continued to talk incessantly about them. The worried mother brought Sarah to the emergency room.  The emergency physician examined her carefully and found no bugs and no evidence left by any bugs.  Her mother stated that Sarah had started taking a stimulant, Adderall XR, about three weeks prior.
 The diagnosis that I wrote in Sarah’s chart that night was “stimulant-induced psychotic disorder.”  Sarah’s mother was instructed to discontinue Adderall as it was the likely cause of the Sarah’s psychosis which had manifested as visual hallucinations (seeing bugs) and tactile hallucinations (feeling bugs).  Methamphetamine (the illicit substance sold by drug dealers) and Dextroamphetamine (the primary substance in many ADHD meds) differ in only one molecule.  This molecule allows methamphetamine to act faster and stronger, but both types of amphetamine do the same thing: They increase the amount of dopamine available to neurons in the brain.  It might appear confusing to give a stimulant to a child who already appears overly stimulated.  However, the areas of the brain that control attention are, in fact, stimulated by the increased dopamine, thus allowing a child with ADHD to have more focus.
Pediatricians and family practice doctors are the ones who write most stimulant prescriptions despite being much less educated on diagnosing and treating ADHD. Managed care companies further restrict access to child psychiatrists by refusing reimbursement for visits to specialists.  Clearly, stimulants are being prescribed to children who do not have ADHD. Stimulant overuse is a serious public health concern that poses significant and unnecessary risks to the safety of America’s children.